Address: Yuanbaoshan Industrial Zone, Chifeng City, Inner Mongolia, China
-
About Us
-
Strength
-
-
Contacts
Pharmacological effects and contraindications of tetracycline
Published on:
2022-02-15
Tetracycline was found in 1940. It was popular for...
1、 Overview of tetracycline
Tetracycline was found in 1940. It was popular for a while. Tetracycline antibiotics can produce antibacterial effect by preventing the extension of peptide chain and protein synthesis of sensitive bacteria. Tetracycline antibiotics have a wide antibacterial spectrum and have strong effects on Gram-negative bacteria, Gram-positive bacteria, spirochetes, chlamydia, Rickettsia, mycoplasma, actinomycetes and Amoeba protozoa.
2、 Classification of veterinary drugs
Tetracycline antibiotics for animals are a kind of broad-spectrum antibiotics with tetrabenzene structure. They are mainly divided into natural and semi synthetic antibiotics. They can be taken orally, have a wide antibacterial spectrum, have low toxicity, few allergies and serious drug resistance, but have weak inhibitory effect on bacterial growth (less than penicillins or streptomycin).
Tetracycline antibiotics for animals mainly include oxytetracycline, tetracycline, aureomycin, doxycycline, minocycline, methylenemycin, etc. they have their own emphasis on the treatment effect, and the dosage requirements are also different. In the use of different types of livestock, we should pay attention to follow the doctor's advice or the requirements of the product manual.
3、 Veterinary drug action
Although tetracycline antibiotics for animals have a wide range of effects, they should be used in an appropriate amount and in a timely manner, because they should also take into account the toxic and side effects of this drug and the adverse reactions of tetracycline drugs: mainly local irritation, double infection and damage to the liver. Local irritation is manifested by oral administration of this kind of antibiotics, which directly stimulates the digestive tract mucosa; After intramuscular injection, because its hydrochloride is strongly acidic, it can cause local pain, inflammation and necrosis; Phlebitis and thrombosis can occur after intravenous injection. Among them, aureomycin was the strongest, oxytetracycline was the second, and tetracycline was the lightest.
4、 Attention to tetracycline for pigs
1. Fast intravenous injection is forbidden to prevent sudden collapse.
2. This product cannot be combined with penicillins, cephalosporins, fluoroquinolones and other fast acting Bactericides to avoid reducing the effect of the latter.
3. It should not be mixed with other drugs to avoid precipitation or effect reduction.
5、 Chicken tetracycline attention
Tetracycline has great side effects on chickens. It can not only stimulate the digestive tract and damage the liver, but also combine with calcium ions, magnesium ions and other metal ions in the chicken digestive tract to form a complex, which hinders the absorption of calcium. At the same time, aureomycin can also combine with calcium ions in plasma to form insoluble calcium salts, which are excreted from the body, resulting in calcium deficiency in the chicken body, thus hindering the formation of eggshell, resulting in soft shell eggs and poor quality of eggs,, It also reduces the laying rate of chickens. Therefore, when using tetracycline antibiotics, we should avoid feeding soybeans, black beans and their cake, and should not feed feed feed additives such as stone powder, bone powder, eggshell powder and gypsum.
Doxycycline hydrochloride is commonly used in these 7 cases:
1. Bacterial diseases are mostly used in respiratory tract, such as pleuropneumonia, porcine lung disease and other diseases. Doxycycline hydrochloride + florfenicol + antipyretic drugs are effective;
2. Actinomycetes, that is, abscesses that can grow in all parts of pigs, except Streptococcus pyogenes. Another situation is caused by actinomycetes. Generally, doxycycline hydrochloride has a better effect;
3. Common "body" diseases; Mycoplasma, that is, asthma, doxycycline hydrochloride + florfenicol (zhiyuanjing) have good effects;
4. Chlamydia, the first is sow abortion, fetal pearl, to consider, with doxycycline hydrochloride treatment effect is better; In the second kind of conjunctivitis, the eye drops of tetracycline drugs are better;
5. Spirochetes (swine dysentery, etc.) and Rickettsia are rarely used, so I won't say more;
6. Toxoplasma gondii is blood protozoa, that is, we often say Eperythrozoon and other diseases. Doxycycline hydrochloride has a better effect;
7. Doxycycline hydrochloride is generally used in prevention and treatment of sows, with less damage and more moderate effect; Doxycycline hydrochloride is mostly used in the feces of suckling piglets, which often appear after seven days, yellow with white and white with gray; Fat pigs often have fever and rebound in dog days.
Key words：